The Gem of Life is a large, red ruby that resides in the Sand Island Statue on Sand Island and has magical properties in Pocket God, Pocket God: Journey To Uranus and the Pocket God Comics. It is so important in the latter that it is the namesake of the the first series of the comic.
The Cursed Idol is a bronze statuette that serves as a recuring character in the Happy Tree Friends universe. It is based on the fertility idol from Indiana Jones and the Raiders of the Lost Ark. It brings death or severe injuries to those who are near it.
The Chaos Emeralds (カオスエメラルド Kaosu Emerarudo?) are seven ancient relics of great power, from the Sonic the Hedgehog video games.
The Dark Star is an artifact featured prominently in Mario & Luigi: Bowser's Inside Story. Long before the time of the game, it was discovered by Toad archaeologists. It attacked the kingdom, and was sealed away by the Star Sprites.
What is this Gem of Cyttorak that can change a human being to such degree? Apparently, it is a magical artifact, somehow linked to a deity called Cyttorak. Over the years, artists‘ interpretations of the gem have varied.